It was found that when a special biomedical protein bandage was used while intermittent fasting, the bones of old mice recovered to a level similar to that of young mice. Although this is the result of an animal experiment, there is interest in whether a breakthrough in innovative treatment that can rejuvenate the bones of the elderly will be made.
To gain insight into bone aging, researchers at the University of Lausanne in Switzerland analyzed changes occurring in the calvaria of a mouse model, which is most vulnerable to aging. We also observed the suture mesenchyme that attaches several pieces of the skull and the periosteum that covers the bones. The periosteum contains blood vessels, lymphatic vessels, and sensory nerves, and contains osteoblasts involved in bone formation.
The researchers found that both bone structure and healing capacity decreased significantly as the mice aged. Beginning in adulthood, blood vessels in the periosteum have decreased. Aged mice have decreased bioenergetic pathways, especially mitochondrial function. Due to these changes, osteoprogenitor cells (a type of stem cell that plays an important role in bone formation and repair) decrease and their function decreases, weakening the ability to restore bone health.
The research team attempted to increase the number of osteoprogenitor cells in aged mice using the Wnt3a bandage, a biomedical device that delivers the Wnt3a protein, which is important in regulating osteoprogenitor cells. Although the number of osteoprogenitor cells increased, the healing ability was not restored.
The research team combined intermittent fasting with Wnt3a bandage treatment in old mice with bone defects. Intermittent fasting has been shown to increase bone density in adult animals.
The older mice recovered their bones to a level similar to that of much younger mice. Intermittent fasting rejuvenated osteoprogenitor cells by promoting mitochondrial activity and reducing aging-related cellular stress.
Additionally, changes in the intestinal microbial community, particularly the increase in the bacteria Akkermansia muciniphila, played an important role in tissue health and recovery. This suggests that changes in diet affect bone health.
Shukri Habib, professor of biomedical sciences at the University of Lausanne, said, “It shows that improving the gut microbiome can reverse aging tissue,” and added, “Aging tissue also has the potential to restore health.”
This study was published in the journal ‘eLife’ under the title ‘Rejuvenating aged osteoprogenitors for bone repair’.
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Source: kormedi.com
